Piglets with Hypoxic-Ischemic Brain Damage Benefit from Cannabidiol and Therapeutic Hypothermia

Cannabidiol (CBD) is a component of the cannabis (marijuana) plant that serves a wide variety of medicinal purposes (the legality of CBD and other cannabis products varies by state). Importantly, cannabidiol has been shown to provide neuroprotection in animal models of hypoxic-ischemic encephalopathy (HIE). HIE is a type of brain injury from oxygen deprivation. In newborns, HIE is often the result of a medical complication or incidence of malpractice during labor and delivery, i.e. a birth injury. Brain damage from HIE is an evolving process; shortly after the initial oxygen-depriving insult, cells begin to die and release substances that are toxic to other cells. A great deal of research on treatments for HIE focuses on slowing or halting this spread of injury. Currently, the most widely used and effective treatment for newborns with HIE is therapeutic hypothermia, also known as neonatal cooling. If administered very shortly after birth, therapeutic hypothermia can…

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