OECD Evaluates Application of In Vitro Methods for Human Hazard Assessment in OECD Testing Program for Safety of Manufactured Nanomaterials

The Organization for Economic Cooperation and Development (OECD) has published a March 23, 2018, report entitled Evaluation of in vitro methods for human hazard assessment applied in the OECD Testing Programme for the Safety of Manufactured Nanomaterials.  The Testing Program for the Testing of Manufactured Nanomaterials tested 11 manufactured nanomaterials to generate information, including their physico-chemical properties, environmental fate, and environmental and mammalian toxicity.  The purpose of the evaluation was to review the Testing Program dossiers and evaluate which of the existing in vitro OECD Test Guidelines (TG) were used, what other non-guideline methods were applied, and what were the potential limitations of each assay used for testing manufactured nanomaterials.  The report lists the following general observations: A number of in vitro methods were used in the OECD Testing Program to assess manufactured nanomaterials, however, many in vitro…

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